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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization

Fig. 7

miR-146a-5p-modified UC-MSCs enhance the efficacy of anti-inflammation and renal function improvement in DN rats. UC-MSCs and miR-146a-5p-modified UC-MSCs were intravenously administrated to explore the renal protection and macrophage polarization regulation of miR-146a-5p on DN rats. a Renal function was assessed by measuring serum creatinine, serum urea nitrogen, 24 h total urine protein and creatinine clearance rate in rats. b, c Concentration of IL-1β and IL-10 in the kidney and serum from each group of rats as measured by ELISA, n = 4 rats/group. d, e Infiltrated neutrophils in the kidney as represented by Ly6G immunohistochemistry staining. f, g Infiltrated macrophages in the kidney as represented by F4/80 immunofluorescence staining, n = 3 rats/group, Scale bar: 100 µm

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Stem Cell Research & Therapy

ISSN: 1757-6512