Fig. 5From: Intrarenal arterial administration of human umbilical cord-derived mesenchymal stem cells effectively preserved the residual renal function of diabetic kidney disease in ratHUCDMSCs therapy suppressed apoptotic, fibrotic and autophagic biomarkers in kidney parenchyma by day 60 after DKD induction. A Protein expression of cleaved caspase-3 (c-Csp3), * versus other groups with different symbols (†, ‡, §), p < 0.0001. B Protein expression of cleaved poly (ADP-ribose) polymerase (c-PARP), * versus other groups with different symbols (†, ‡, §), p < 0.0001. C Protein expression of mitochondrial Bax (mit-Bax), * versus other groups with different symbols (†, ‡, §), p < 0.0001. D Protein expression of transforming growth factor (TGF)-ß, * versus other groups with different symbols (†, ‡, §), p < 0.0001. E Protein expression of phosphorylated (p)-Smad3, * versus other groups with different symbols (†, ‡, §), p < 0.0001. F Protein expression of the ratio of LC3B-II to LC3B-I, * versus other groups with different symbols (†, ‡, §), p < 0.0001. G Protein expression of Atg5, * versus other groups with different symbols (†, ‡, §), p < 0.0001. H Protein expression of beclin-1, * versus other groups with different symbols (†, ‡, §), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). SC = sham-operated control; DKD = diabetic kidney disease; HUCDMSCLow = human umbilical cord-derived mesenchymal stem cell of lower dose (2.1 × 105 cells); HUCDMSCHigh = human umbilical cord-derived mesenchymal stem cell of higher dose (6.3 × 105 cells)Back to article page