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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Intrarenal arterial administration of human umbilical cord-derived mesenchymal stem cells effectively preserved the residual renal function of diabetic kidney disease in rat

Fig. 5

HUCDMSCs therapy suppressed apoptotic, fibrotic and autophagic biomarkers in kidney parenchyma by day 60 after DKD induction. A Protein expression of cleaved caspase-3 (c-Csp3), * versus other groups with different symbols (†, ‡, §), p < 0.0001. B Protein expression of cleaved poly (ADP-ribose) polymerase (c-PARP), * versus other groups with different symbols (†, ‡, §), p < 0.0001. C Protein expression of mitochondrial Bax (mit-Bax), * versus other groups with different symbols (†, ‡, §), p < 0.0001. D Protein expression of transforming growth factor (TGF)-ß, * versus other groups with different symbols (†, ‡, §), p < 0.0001. E Protein expression of phosphorylated (p)-Smad3, * versus other groups with different symbols (†, ‡, §), p < 0.0001. F Protein expression of the ratio of LC3B-II to LC3B-I, * versus other groups with different symbols (†, ‡, §), p < 0.0001. G Protein expression of Atg5, * versus other groups with different symbols (†, ‡, §), p < 0.0001. H Protein expression of beclin-1, * versus other groups with different symbols (†, ‡, §), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). SC = sham-operated control; DKD = diabetic kidney disease; HUCDMSCLow = human umbilical cord-derived mesenchymal stem cell of lower dose (2.1 × 105 cells); HUCDMSCHigh = human umbilical cord-derived mesenchymal stem cell of higher dose (6.3 × 105 cells)

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