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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Intrarenal arterial administration of human umbilical cord-derived mesenchymal stem cells effectively preserved the residual renal function of diabetic kidney disease in rat

Fig. 6

HUCDMSCs therapy reduced oxidative stress markers in kidney parenchyma by day 60 after DKD induction. A Protein expression of NOX-1, * versus other groups with different symbols (†, ‡, §), p < 0.0001. B Protein expression of NOX-2, * versus other groups with different symbols (†, ‡, §), p < 0.0001. C Protein expression of p22phox, * versus other groups with different symbols (†, ‡, §), p < 0.0001. D The oxidized protein expression, * versus other groups with different symbols (†, ‡, §), p < 0.0001, p < 0.0001 (Note: the left and right lanes shown on the upper panel represent protein molecular weight marker and control oxidized molecular protein standard, respectively). M.W. = molecular weight; DNP = 1–3 dinitrophenylhydrazone. E Protein expression of superoxide dismutase (SOD), * versus other groups with different symbols (†, ‡, §), p < 0.0001, p < 0.0001. F–I The microscopic finding (200x) for identification of cellular expression of 8-hydroxy-2' -deoxyguanosine (8-OHdG) (gray color). J Analytical result of expression of 8-OHdG, * versus other groups with different symbols (†, ‡, §), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). SC = sham-operated control; DKD = diabetic kidney disease; HUCDMSCLow = human umbilical cord-derived mesenchymal stem cell of lower dose (2.1 × 105 cells); HUCDMSCHigh = human umbilical cord-derived mesenchymal stem cell of higher dose (6.3 × 105 cells)

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