Fig. 7
HUCDMSCs therapy reduced mitochondrial and DNA-damaged biomarkers in kidney parenchyma by day 60 after DKD induction. A Protein expression of cytosolic cytochrome C (cyt-CytC), * versus other groups with different symbols (†, ‡, §), p < 0.0001. B Protein expression of DRP1, * versus other groups with different symbols (†, ‡, §), p < 0.0001. C Protein expression of γ-H2AX, * versus other groups with different symbols (†, ‡, §), p < 0.0001. D Protein expression of mitochondrial cytochrome C (mit-CytC), * versus other groups with different symbols (†, ‡, §), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). SC = sham-operated control; DKD = diabetic kidney disease; HUCDMSCLow = human umbilical cord-derived mesenchymal stem cell of lower dose (2.1 × 105 cells); HUCDMSCHigh = human umbilical cord-derived mesenchymal stem cell of higher dose (6.3 × 105 cells)