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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Epiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signaling

Fig. 2

The established acquired resistant cells had stemness and EMT ability. A The cell viability of A549-CR or A549-TR cells treated with 4 µg/mL cisplatin or 100 ng/mL taxol for 72 h, n = 3. B RT-qPCR detection for the screened resistant genes in A549-CR or A549-TR cells, n = 3. C The hazard ratios of first progression survival time for the validated resistant genes between highly expressed population and lowly expressed population. D The spheres forming ability of the A549-CR or A549-TR cells compared with A549 cells (2000 cells input, n = 3). E RT-qPCR detection for stemness-associated genes expression A549-CR or A549-TR cells compared with A549 cells, n = 3. F RT-qPCR detection for EMT-related genes expression in A549-CR or A549-TR cells compared with A549 cells, n = 3. h, hours; CR, cisplatin resistance; TR, taxol resistance; HR, hazard ratio; CIs, confidence interval; *, p < 0.05; **, p < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512