Fig. 5

Restoration of PPARα and PGC1α expression not involved in Hypo-EVs induced better recovery of FAO. a Schematic illustration for FAO regulation. PPARα and PGC1α are the major regulators of FAO. Promoting the activity of PPARα can boost FAO, and PGC1α is a coactivator of PPARα. b The mRNA level of PPARα in different groups (n = 6). c The mRNA level of PGC1α in different groups (n = 6). d, e Western blot analysis was used to detect the protein expression of PGC1α. The relative expression of PGC1α was evaluated. Data are expressed as mean ± SEM. *P < 0.05 and ** P < 0.01