From: Meniscus repair: up-to-date advances in stem cell-based therapy
Injury model | Animal | Cell source | Cell density | Implant form | Stimuli | Duration | Year/References |
---|---|---|---|---|---|---|---|
4 mm longitudinal meniscus tear | Rabbit | BMSCs | – | Bone marrow aspirate concentrate | – | 12 weeks | 2019/[89] |
Meniscus tears | Rat meniscus explant | C-PCs | 1.0 × 105 | Co-culture | Stromal cell-derived factor-1 (SDF-1) | 20 days | 2018/[91] |
Partial meniscectomy | Rabbit | ADSCs | – | High-density mesenchymal stem cell, scaffold-free allograft constructs | – | 12 weeks | 2016/[93] |
Punctuated injury | Minipig | SMSCs | 2.0 × 107 | Suspension | – | 8 weeks | 2021/[94] |
Partial meniscectomy | Cynomolgus | SMSCs | 2.5 × 105 | Aggregates | – | 16 weeks | 2017/[95] |