Skip to main content
Fig. 13 | Stem Cell Research & Therapy

Fig. 13

From: Assessing the impact of gestational age of donors on the efficacy of amniotic epithelial cell-derived extracellular vesicles in experimental bronchopulmonary dysplasia

Fig. 13

Invasive lung function test on 6-week-old mice (n = 6). A, B There were no significant differences in the baseline of either respiratory resistance (Rrs, A) or compliance (Crs, B) between groups. C–D Compared to control group, Rrs was significantly increased (C) and Crs was significantly decreased (D) at the 100 mg/ml methacholine dose in the injured group, but this effect was diminished with hAEC treatment and also improved with term EV treatment groups. (E) Pressure volume loop (PV loop) on week 6. There was a significant upward shift of the PV loop in the injured group compared to the control group. While the PV loop of both hAEC treatment group and term EV treatment group was intermediate to both control and saline-treated injured groups, preterm EV treatment had no effect on the position of the PV loop. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512