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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Assessing the impact of gestational age of donors on the efficacy of amniotic epithelial cell-derived extracellular vesicles in experimental bronchopulmonary dysplasia

Fig. 9

Bronchioalveolar stem cells (BASCS) and type II alveolar cells (AT2s) in mouse lungs at PND7 and PND14 (n = 6). A Representative image of pro-SPC (red) and CC10 (green) immunohistochemical staining on mouse lung tissues where arrows point to BASCs (scale bars = 50 μm). B, C The average number of BASCs per terminal bronchiole on PND7 (B) and PND14 (C). In contrast to hAEC treatment group, where the average number of BASCs was significantly higher than control group on PND14, it did not change in EV groups on both time points. D, E The percentage of AT2 cells was significantly increased in term EV treatment group on both PND7 (D) and 14 (E) compared to control group, which is on contrast to the unchanged AT2 cell percentage in both hAEC and preterm EV treatment groups (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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Stem Cell Research & Therapy

ISSN: 1757-6512