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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The circadian clock has roles in mesenchymal stem cell fate decision

Fig. 2

a Both PPARγ and its cofactor PGC-1α serve as master transcription factors in adipogenic differentiation and are tightly regulated by the circadian clock. b miR-7-5p liberates CRY from the BMAL1-CLOCK complex to promote the transcription of P300. P300 and RUNX2 act simultaneously on the targeted promoter. c BMAL1 promotes the expression of SOX9 and PER1 inhibits SOX6 expression

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