Table 1 Characteristics of the included trials
Study | Country | Type of cell | Sample size | Mean age | Male% | Baseline LVEF (%) | Injection time (days) | Modality | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inv | Cont | Inv | Cont | Inv | Cont | Inv | Cont | |||||
Assmus [13] | Germany | BM-MNCs | 101 | 103 | 55 ± 11 | 57 ± 11 | 82 | 82 | 47.5 ± 10 | 46.7 ± 10.3 | 4.4 ± 1.3 | LV angiography |
Beitnes [14] | Norway | BM-MNCs | 50 | 50 | 58.1 ± 8.5 | 56.7 ± 9.6 | 84 | 84 | 45.7 ± 9.4 | 46.9 ± 9.6 | 4–8 | Echo/CMR |
Cao [15] | China | BM-MNCs | 41 | 45 | 50.7 ± 1.1 | 51.0 ± 1.0 | 95 | 93 | 39 ± 3 | 38.6 ± 3 | 7 | Echo/SPECT |
Ge [16] | China | BM-MNCs | 10 | 10 | 58 ± 11 | 59 ± 8 | 80 | 100 | 53.8 ± 9.2 | 58.2 ± 7.5 | 0–1 | Echo/SPECT |
Grajek [17] | Poland | BM-MNCs | 31 | 14 | 49.9 ± 8.4 | 50.9 ± 9.3 | 87 | 86 | 50.32 ± 9.8 | 50.84 ± 11.97 | 4–5 | Echo/SPECT |
Hirsch [18] | Netherlands | BM-MNCs | 69 | 65 | 56 ± 9 | 55 ± 10 | 84 | 86 | 43.7 ± 9 | 42.4 ± 8.3 | 8 | CMR |
Hu [19] | China | BM-MNCs | 22 | 14 | 60.45 ± 11.4 | 60.62 ± 10.85 | 86 | 64 | 53.8 ± 11.5 | 57.1 ± 11.6 | 5 | Echo/SPECT |
Huang [20] | China | BM-MNCs | 79 | 25 | 58.55 ± 8.72 | 58.8 ± 8.4 | 91 | 88 | 43.65 ± 5.21 | 43.5 ± 3.5 | 1–30 | Echo/SPECT |
Huikuri [21] | Finland | BM-MNCs | 40 | 40 | 60 ± 10 | 59 ± 10 | 90 | 85 | 59 ± 11 | 62 ± 12 | 2–6 | Echo/LV angiography |
Janssens [22] | Belgium | BM-MNCs | 33 | 34 | 55.8 ± 11 | 57.9 ± 10 | 82 | 82 | 48.5 ± 7.2 | 46.9 ± 8.2 | 1 | Echo/CMR |
Meluzin [23] | Czech | BM-MNCs | 40 | 20 | 54 ± 2 | 55 ± 2 | 92 | 90 | 40.5 ± 8.94 | 40 ± 8.94 | 3–8 | Echo/SPECT |
Meyer [24] | Germany | BM-MNCs | 30 | 30 | 53.4 ± 14.8 | 59.2 ± 13.5 | 67 | 73 | 50 ± 10 | 51.3 ± 9.3 | 4.8 ± 1.3 | CMR |
Nicolau [25] | Brazil | BM-MNCs | 66 | 55 | 59.23 ± 9.44 | 58.72 ± 9.3 | 80 | 82 | 44.63 ± 10.74 | 42.23 ± 10.33 | 6–9 | CMR |
Nogueira [26] | Brazil | BM-MNCs | 24 | 6 | 57.2 ± 10.9 | 57.2 ± 10.8 | 71 | 67 | 48.41 ± 8.28 | 47.59 ± 14.31 | 4–7.5 | Echo |
Piepoli [27] | Italy | BM-MNCs | 19 | 19 | 63.1 ± 2.4 | 67 ± 2.7 | 68.4 | 68.4 | 38.9 ± 1.3 | 38.4 ± 1.5 | 4–7 | Echo/SPECT |
Plewka [28] | Poland | BM-MNCs | 40 | 20 | 56 ± 9 | 56 ± 9 | 67 | 75 | 35 ± 6 | 33 ± 7 | 7 | Echo/SPECT |
San Roman [29] | Spain | BM-MNCs | 30 | 31 | 54 ± 11 | 57 ± 11 | 97 | 90 | 49 ± 8 | 47 ± 8 | 3–5 | CMR/LV angiography |
Skalicka [30] | Czech | BM-MNCs | 17 | 10 | 61 ± 14 | 54 ± 10 | 71 | 100 | 39.2 ± 9.2 | 39.4 ± 5.6 | 4–11 | Echo/SPECT |
Sürder [31] | Switzerland | BM-MNCs | 128 | 67 | 58.44 ± 10.92 | 56 ± 10.74 | 84 | 84 | 36.4 ± 8.92 | 40 ± 9.9 | 5–28 | CMR |
Traverse [32] | USA | BM-MNCs | 58 | 29 | 57.6 ± 11 | 54.6 ± 11 | 79 | 90 | 48.7 ± 12 | 45.3 ± 9.9 | 14–21 | CMR |
Traverse [33] | USA | BM-MNCs | 30 | 10 | 52.5 ± 15.56 | 57.5 ± 3.7 | 83 | 60 | 49 ± 9.5 | 48.6 ± 8.5 | 3–10 | CMR/Echo |
Traverse [34] | USA | BM-MNCs | 58 | 27 | 55.9 ± 11 | 56.4 ± 10.4 | 88 | 86 | 45.9 ± 9.4 | 46.9 ± 8.7 | 3–7 | CMR |
Turan [35] | Germany | BM-MNCs | 42 | 20 | 61 ± 15 | 60 ± 11 | 67 | 70 | 43 ± 10 | 45 ± 10 | 7 | Left Ventriculography |
Wöhrle [36] | Germany | BM-MNCs | 29 | 13 | 61 ± 8.1 | 61.1 ± 9.3 | 90 | 62 | 53.5 ± 9.3 | 55.7 ± 9.4 | 5–7 | CMR |
Wollert [37] | Germany | BM-MNCs | 127 | 26 | 55.46 ± 9.83 | 55 ± 9 | 85 | 92 | 44.3 ± 8.48 | 47.8 ± 6.7 | 7.1 ± 2.6 | CMR |
Yao [38] | China | BM-MNCs | 27 | 12 | 51.7 ± 6.4 | 52.7 ± 7.8 | 81 | 92 | 33.2 ± 3.9 | 32.3 ± 2 | 3d–3 m | CMR |
Chullikana [39] | India | MSCs | 10 | 10 | 47.31 ± 12.1 | 47.79 ± 6.48 | 100 | 80 | 43 ± 3.63 | 43.44 ± 4.4 | 2 | Echo |
Gao [40] | China | MSCs | 21 | 22 | 55.0 ± 1.6 | 58.6 ± 2.5 | 100 | 86 | 50.2 ± 6.87 | 51.2 ± 7 | 17.1 ± 0.6 | Echo |
Gao [41] | China | MSCs | 58 | 58 | 57.3 ± 1.3 | 56.7 ± 1.7 | 95 | 88 | 52 ± 0.9 | 51.1 ± 1 | 5–7 | Echo |
Hare [8] | USA | MSCs | 34 | 19 | 59 ± 12.3 | 55.1 ± 10.2 | 79 | 82 | 48.7 ± 9.6 | 50.4 ± 10.6 | – | Echo |
Houtgraaf [42] | Netherlands | MSCs | 9 | 4 | 61 ± 2.1 | 55 ± 7.5 | 78 | 100 | 52.1 ± 2.5 | 52 ± 10 | 1 | SPECT |
Kim [43] | South Korea | MSCs | 14 | 12 | 55.3 ± 8.6 | 57.8 ± 8.9 | 100 | 100 | 35.1 ± 4.5 | 37.4 ± 1.7 | 30 ± 1.3 | Echo/SPECT |
Lee [44] | South Korea | MSCs | 30 | 28 | 53.9 ± 10.5 | 54.2 ± 7.7 | 90 | 89 | 48.1 ± 8 | 51 ± 9.2 | 25 ± 2.4 | Echo/SPECT |
Penn [45] | USA | MSCs | 19 | 6 | 56.8 ± 8.7 | 53 ± 8 | 63 | 83 | 47.9 ± 10.2 | 42.3 ± 6.4 | 3.3 | Echo |
Rodrigo [46] | Netherlands | MSCs | 9 | 45 | 56 ± 8 | 61 ± 11 | 78 | 78 | 48 ± 2 | 45 ± 9 | 21 ± 3 | Echo |
Zhang (47) | China | MSCs | 21 | 22 | 59.3 ± 9 | 58.6 ± 11 | 95 | 86 | 57.2 ± 10.2 | 53.7 ± 6.4 | 14 ± 9.5 | Echo |