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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Human integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype

Fig. 2

Cartilage defect in the rabbit knee. A The defect was made with a handheld drill that ensured a defect size of 2.5 mm in diameter and 1.1 ± 0.1 mm in depth. B Arthrotomy was performed through a medial parapatellar incision and lateral displacement of the patella. A chondral defect was made in the trochlear groove of the femur of the rabbits. C Magnified image of the surgically created chondral defect (arrow). D Safranin O fast green-stained histology slice of a partly healed cartilage defect (rabbit #8, day 10 after integrin ⍺10-MSC injection). Cartilage is red and bone is blue. E Partially healed defect (arrow) (rabbit #1, day 7 after integrin ⍺10-MSC injection)

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