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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype

Fig. 3

Visualization of labeled integrin α10-MSCs. A Fluorescence microscopy image of six individual integrin α10-MSCs labeled with Molday Ion conjugated with Rhodamine B (MIRB) (25 µg/ml for 6 h). B MRI (T2*W) of phantoms containing different concentrations of MIRB-labeled integrin α10-MSCs. The MSCs were labeled with MIRB for 6 h (6h-MIRB-MSCs) or 16 h (16h-MIRB-MSCs) or left unlabeled (UL) and agarose phantoms were created by embedding integrin α10-MSCs in 0.2 mL agar in micro-Eppendorf tubes. Tubes were MRI scanned in transverse and sagittal view with a T2*W FLASH sequence. The individual labeled cells can be seen as black dots, whereas unlabeled cells cannot be detected. 10 k = 10,000 cells; 25 k = 25,000 cells; 50 k = 50,000 cells; 75 k = 75,000 integrin α10-MSCs

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