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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Human integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype

Fig. 6

Magnetic resonance imaging (MRI) detection of MIRB-labeled integrin α10-MSCs in a cartilage defect. A focal cartilage defect was created surgically and MIRB-labeled integrin α10-MSCs were injected 7 days later. 3D-FLASH MRI coronal (A) and 3D-FISP MRI sagittal (B) views of the knee of rabbit #1 and #6 at baseline (after surgery but before injection), 12 h (12h), 4 days (4d) and 7d after integrin α10-MSC injection. The chondral defect is indicated (dotted lined box) and inserts show the magnification of the cartilage defect area. Labeled integrin α10-MSCs aggregating in the defect are detected as hypointense black material. MIRB Molday ion conjugated with Rhodamine B

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