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Table 1 Visual grading of integrin α10-MSC distribution on magnetic resonance images

From: Human integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype

 

0 h

12 h

24 h

2 days

4 days

7 days

10 days

Rabbit 1

Cartilage Defect

 

 +++ 

  

 ++ 

 + 

 

Surrounding Cartilage

 

0

  

0

0

 

Synovial Membrane

 

 +++ 

  

 + 

 + 

 

Infrapatellar Fat Pad

 

 + 

  

0

0

 

Rabbit 2

Cartilage Defect

  

 + 

 

 + 

 

0

Surrounding Cartilage

  

0

 

0

 

0

Synovial Membrane

  

 ++ 

 

 + 

 

 + 

Infrapatellar Fat Pad

  

0

 

0

 

0

Rabbit 4

Cartilage Defect

0

  

 + 

 + 

 

0

Surrounding Cartilage

0

  

0

0

 

0

Synovial Membrane

 ++ 

  

 ++ 

 + 

 

0

Infrapatellar Fat Pad

0

  

0

0

 

0

Rabbit 5

Cartilage Defect

 + 

 

 + 

 

 + 

  

Surrounding Cartilage

 + 

 

0

 

0

  

Synovial Membrane

 ++ 

 

 + 

 

 + 

  

Infrapatellar Fat Pad

 + 

 

0

 

0

  

Rabbit 6

Cartilage Defect

 

 ++ 

 

 ++ 

 + 

 + 

 

Surrounding Cartilage

 

0

 

0

0

0

 

Synovial Membrane

 

 ++ 

 

 + 

 + 

 + 

 

Infrapatellar Fat Pad

 

 + 

 

 + 

0

0

 
  1. Distribution of labeled mesenchymal stem cells selected for a high expression of integrin α10β1 (integrin α10-MSCs) after intra-articular injection in the knee of 6 rabbits with a surgically created cartilage defect. The distribution is determined by visual grading of magnetic resonance images. Distribution and cell concentration was graded subjectively as 0 = none; +  = mild; ++  = moderate; +++  = marked; gray box = rabbit not scanned at that timepoint. Rabbit #3 was removed from the study because of unintentional peri-articular injection of labeled α10-MSCs