From: Advances in the application of low-intensity pulsed ultrasound to mesenchymal stem cells
Cell source | Study | LIPUS parameter | Effects on MSCs | Therapeutic application | ||
---|---|---|---|---|---|---|
Intensity (mW/cm2) | Frequency (MHz) | Time (min) | ||||
BMSCs | Yang et al. | Unclear | 1.02 | 7.3 | Viability | – |
 | Xie et al. | 50/60 | 1.5 | 5/10 | Proliferation | – |
 | Aliabouzar et al. | 100 | 1.5 | 3 | Chondrogenic differentiation | – |
 | Zhi et al. | 100/150/200 | 1 | 15 | Chondrogenic differentiation | – |
 | Xia et al. | 40 | 3 | 20 | Chondrogenic differentiation | – |
 | Wang et al. | 50 | 3 | 20 | Chondrogenic differentiation | – |
 | An et al. | 100 | 1 | 10 | Osteogenic differentiation | – |
 | Kusuyama et al. | 30 | 1.5 | 20 | Chondrogenic and osteogenic differentiation | – |
 | Li et al. | 500/1000/1500 | 1 | 0.5/1 | Hepatic differentiation | – |
 | Wei et al. | 30 | 1.5 | 20 | Migration | Fracture healing |
 | Chen et al. | 30 | 0.25 | 20 | Migration | Fracture healing |
 | Ning et al. | 50 | 1 | 3 | Viability and migration | Spinal cord injury |
 | Wang et al. | 30 | 1.5 | 20 | Migration and osteogenesis | Periodontal regeneration |
 | Xia et al. | 50 | 3 | 20 | Migration and chondrogenesis | Osteoarthritis |
ADSCs | Wang et al. | 70 | 0.5 | 1 | Viability and proliferation | – |
 | Huang et al. | 30 | 1.5 | 5 | Proliferation | – |
 | Jiang et al. | 100 | 1 | 8 | Osteogenic differentiation | – |
 | Yue et al. | 100 | 0.001 | 10 | Osteogenic differentiation | – |
 | Fu et al. | 30 | 1 | 20 | Adipogenic differentiation | – |
 | Kang et al. | 15 | 1 | 5 | Promote angiogenesis of endothelial cells | Wound and tissue healing |
 | Yue et al. | 20 | 1 | 10 | Promote myelination of Schwann cells | Peripheral nerve injury |
 | Chen et al. | 30 ± 5 | 1.5 | 20 | Chondrogenesis and osteogenesis | Bone–tendon healing |
PDLSCs | El-Bialy et al. | 30 | 1.5 | 10 | Proliferation and osteogenic differentiation | – |
 | Hu et al. | 90 | 1.5 | 20 | Osteogenic differentiation | – |
 | Kusuyama et al. | Unclear | unclear | 20 | Osteogenic differentiation | – |
 | Wang et al. | 90 | 1.5 | 30 | Migration | – |
 | Gao et al. | 250 | 1 | 5 | Proliferation | – |
DPSCs | Gao et al. | 750 | 1 | 5 | Proliferation | – |
ABMSCs | Lim et al. | 50 | 1 | 10 | Viability and osteogenic differentiation | – |
GMSCs | El-Bialy et al. | 30 | 1.5 | 10 | Neuronal differentiation | – |
AD-MSCs | Ling et al. | 30 | 0.25 | 30 | Proliferation | – |
 | Ling et al. | 30 | 0.25 | 30 | Promote ovarian regeneration | Primary ovarian insufficiency |
UCMSCs | Yoon et al. | 25–35 | 0.04 | 1.67/5/10 | Viability and proliferation | – |
 | Chen et al. | 30/50 | 1.5 | 5 | Proliferation | – |
LIPUS combined with microbubbles | ||||||
---|---|---|---|---|---|---|
BMSCs | Aliabouzar et al. | 30 | 1.5 | 1/3/5 | Proliferation and chondrogenic differentiation | – |
 | Osborn et al. | 30 | 1.5 | 3 | Proliferation and osteogeneic Differentiation | – |
 | Li et al. | 600 | 1 | 0.5 | Migration | Myocardial infraction |
 | Wang et al. | 600 | 1 | 0.5 | Migration | Acute kidney injury |
 | Yi et al. | 23 | 1 | 5 | Migration | Chronic bacterial prostatitis |