Fig. 6

In vivo Musashi-1 downregulation limits tumor growth. A Xenograft tumor growth over time in Msi-1-siRNA and control siRNA-treated mice (p < 0.05 after day 24: p = 0.038 at d (day) 24, p = 0.048 at d 28, p = 0.041 at d 31, p = 0.032 at d 35, p = 0.047 at d 38, n = 15). B TERT (telomerase) mRNA expression in Msi-1 depleted tumors compared to controls (p = 0.001, n = 27 for ctrl (mean delta ct value 8.43), n = 21 for Msi-1 KD (mean delta ct value 10.37)). C Dead cell (C1) and mitotic cell (C2) area in Msi-1 depleted tumors compared to controls (n = 14). D Representative pictures of control (left) and Msi-1 depleted (right) tumor microsections after immunofluorescence staining (DNA = blue, mitotic activity = green, dead cells = red)