Skip to main content

Table 1 Characteristics of included studies

From: Mesenchymal stem cells against intestinal ischemia–reperfusion injury: a systematic review and meta-analysis of preclinical studies

Author Year Country Species/gender Age/weight I/R duration Anesthetic MSCs type /dosage Administration Timing of MSCs (post-reperfusion)
AMI 2017 Turkey SD rats/f 200–250 g 45 min/1, 4, 7 d Xylazine/ketamine BM, allogeneic, 0.5/1 × 106 Inferior vena cava/local injection Immediately
Chang 2015 Taiwan SD rats/m 325–350 g 30 min/3 d Unclear AD, autologous, 1.2 × 106 Intravenous and local injection Immediately
Fukuda 2013 Japan ICR mice Unclear 60 min/2, 6 h Unclear AD, autologous, 1 × 105/106 i.p Immediately
Gao 2010 China Wistar rats/m ≈ 200 g 20 min/0.5, 1, 3, 7, 14, 28 d Unclear BM, allogeneic, 1 × 106 Caudal vein Immediately
Geng 2016 China SD rats/m 180–220 g 30 min/2 h Unclear BM, allogeneic, 1 × 107 Caudal vein Immediately
Jensena 2016 USA C57Bl6 mice/m 8–12 w, 20–30 g 60 min/12, 24 h Isoflurane hAD, 2 × 106 i.p Unclear
Jensenb 2016 USA C57Bl6 mice/m 8–12 w, 20–30 g 60 min/12, 24 h Isoflurane hAD, hUD, 2 × 106 i.p Unclear
Jensen 2018 USA C57Bl6 mice/m 8–12 w 60 min/24 h Isoflurane hUD, 2 × 106 i.p Immediately
Jiang 2011 China SD rats/f 180–200 g 45 min/4, 7 d Ketamine BM, allogeneic (m), 1 × 107 Local injection Immediately
Jiang 2013 China SD rats/f 180–220 g 45 min/1, 4, 7 d Ketamine BM, allogeneic (m), 1 × 107 Local injection Immediately
Kong 2020 China SD rats/m 250–300 g 30 min/72 h Pentobarbital AD, allogeneic, 2 × 106 Caudal vein Unclear
Liu 2016 China SD rats 6–8 w/180–210 g 30 min/2, 6, 24, 72, 120 h Unclear BM, allogeneic, 5 × 106 Local injection Unclear
Liu 2020 China C57Bl6 mice 20–25 g 60 min/2 d Pentobarbital AD, allogeneic, 5 × 106 Local injection Unclear
Markel 2015 USA C57Bl6 mice/m 8–12 w/20-30 g 60 min/6 h Isoflurane hBM, 2 × 104/105/106 i.p Unclear
Oliveira 2018 Brazil NZ rabbits ≈ 10 w/≈ 3 kg 2 h/3, 7 d Xylazine, ketamine, tramadol, isoflurane AD, allogeneic, 1.2 × 106 Marginal auricular vein 5 h
Shen 2013 China SD rats/m 120–200 g 30 min/2, 6, 24, 72, 144 h Chloral hydrate BM, allogeneic, 1 × 107 Local injection Immediately
Watkins 2013 USA FVB mice/m 8–10 w/≈ 20 g 60 min/24 h Isoflurane BM/AF (from C57Bl6 mice), 1 × 106 i.p 2 h
Yan 2019 China SD rats/m unclear 60 min/1, 7 d Pentobarbital BM, allogeneic, 1 × 107 i.p Unclear
  1. SD: Sprague–Dawley; f: female; m: male; MSCs: mesenchymal stem cells; BM: Bone marrow; hBM: Human BM; AD: adipose-derived; AF: amniotic fluid; hUD: Human umbilical Cord; NZ: New Zealand; i.p.: intraperitoneal; min: minute(s); h: hour(s); d: day(s); w: week(s); g: gram(s); kg: kilogram(s); USA: United States of America