Mesenchymal stem cells against intestinal ischemia–reperfusion injury: a systematic review and meta-analysis of preclinical studies

Shi, Yajing; Zhang, Xiaolan; Wan, Zhanhai; Liu, Xin; Chen, Feng; Zhang, Jianmin; Leng, Yufang

doi:10.1186/s13287-022-02896-y

Stem Cell Research & Therapy

Table 1 Characteristics of included studies

From: Mesenchymal stem cells against intestinal ischemia–reperfusion injury: a systematic review and meta-analysis of preclinical studies

Author	Year	Country	Species/gender	Age/weight	I/R duration	Anesthetic	MSCs type /dosage	Administration	Timing of MSCs (post-reperfusion)
AMI	2017	Turkey	SD rats/f	200–250 g	45 min/1, 4, 7 d	Xylazine/ketamine	BM, allogeneic, 0.5/1 × 10⁶	Inferior vena cava/local injection	Immediately
Chang	2015	Taiwan	SD rats/m	325–350 g	30 min/3 d	Unclear	AD, autologous, 1.2 × 10⁶	Intravenous and local injection	Immediately
Fukuda	2013	Japan	ICR mice	Unclear	60 min/2, 6 h	Unclear	AD, autologous, 1 × 10⁵/10⁶	i.p	Immediately
Gao	2010	China	Wistar rats/m	≈ 200 g	20 min/0.5, 1, 3, 7, 14, 28 d	Unclear	BM, allogeneic, 1 × 10⁶	Caudal vein	Immediately
Geng	2016	China	SD rats/m	180–220 g	30 min/2 h	Unclear	BM, allogeneic, 1 × 10⁷	Caudal vein	Immediately
Jensena	2016	USA	C57Bl6 mice/m	8–12 w, 20–30 g	60 min/12, 24 h	Isoflurane	hAD, 2 × 10⁶	i.p	Unclear
Jensenb	2016	USA	C57Bl6 mice/m	8–12 w, 20–30 g	60 min/12, 24 h	Isoflurane	hAD, hUD, 2 × 10⁶	i.p	Unclear
Jensen	2018	USA	C57Bl6 mice/m	8–12 w	60 min/24 h	Isoflurane	hUD, 2 × 10⁶	i.p	Immediately
Jiang	2011	China	SD rats/f	180–200 g	45 min/4, 7 d	Ketamine	BM, allogeneic (m), 1 × 10⁷	Local injection	Immediately
Jiang	2013	China	SD rats/f	180–220 g	45 min/1, 4, 7 d	Ketamine	BM, allogeneic (m), 1 × 10⁷	Local injection	Immediately
Kong	2020	China	SD rats/m	250–300 g	30 min/72 h	Pentobarbital	AD, allogeneic, 2 × 10⁶	Caudal vein	Unclear
Liu	2016	China	SD rats	6–8 w/180–210 g	30 min/2, 6, 24, 72, 120 h	Unclear	BM, allogeneic, 5 × 10⁶	Local injection	Unclear
Liu	2020	China	C57Bl6 mice	20–25 g	60 min/2 d	Pentobarbital	AD, allogeneic, 5 × 10⁶	Local injection	Unclear
Markel	2015	USA	C57Bl6 mice/m	8–12 w/20-30 g	60 min/6 h	Isoflurane	hBM, 2 × 10⁴/10⁵/10⁶	i.p	Unclear
Oliveira	2018	Brazil	NZ rabbits	≈ 10 w/≈ 3 kg	2 h/3, 7 d	Xylazine, ketamine, tramadol, isoflurane	AD, allogeneic, 1.2 × 10⁶	Marginal auricular vein	5 h
Shen	2013	China	SD rats/m	120–200 g	30 min/2, 6, 24, 72, 144 h	Chloral hydrate	BM, allogeneic, 1 × 10⁷	Local injection	Immediately
Watkins	2013	USA	FVB mice/m	8–10 w/≈ 20 g	60 min/24 h	Isoflurane	BM/AF (from C57Bl6 mice), 1 × 10⁶	i.p	2 h
Yan	2019	China	SD rats/m	unclear	60 min/1, 7 d	Pentobarbital	BM, allogeneic, 1 × 10⁷	i.p	Unclear

SD: Sprague–Dawley; f: female; m: male; MSCs: mesenchymal stem cells; BM: Bone marrow; hBM: Human BM; AD: adipose-derived; AF: amniotic fluid; hUD: Human umbilical Cord; NZ: New Zealand; i.p.: intraperitoneal; min: minute(s); h: hour(s); d: day(s); w: week(s); g: gram(s); kg: kilogram(s); USA: United States of America

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ISSN: 1757-6512

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