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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic inflammatory microenvironment

Fig. 6

The effect of SNHG8 on NF-κB pathway is dependent on HIF-1α. A Western blot analyses of HIF-1α after DMOG stimulation in PDLCs. B Western blot analyses of HIF-1α following application of force and stimulation of YC-1 (lificiguat, an HIF-1α inhibitor) in PDLCs. C Western blot analyses of phos-p65 and IκBα after the application of compressive force with or without SNHG8 knockdown, and with or without YC-1 stimulation, in PDLCs. D Western blot analyses of phos-p65 and IκBα after the application of compressive force with or without SNHG8 overexpression, and with or without DMOG stimulation, in PDLCs. All histograms show the quantification of band intensities. (Analysis of variance *p < 0.05; **p < 0.01)

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