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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse

Fig. 4

The hair cycle of the hairpoor mouse after depilation is impaired. a Histological analysis of hair cycle after depilation using H&E staining. Telogen, Tel; anagen, An; catagen, Ca; scale bar = 200 μm. b Immunohistochemical analysis of Ki67 in bulge and bulb using 6-μm-thick sections of the wild-type and the hairpoor mouse at 7 days after depilation. Scale bar = 100 μm. c Immunohistochemical staining of LEF1 at 1st and 2nd telogen phase. Arrowhead indicates positive staining. Scale bar = 50 μm. d qRT-PCR analysis of Lef1 in the hairpoor and the wild-type mouse. Expression of Lef1 was normalized against that of Gapdh, and the relative expression level was determined using one of the wild-type levels as reference. n = 4 per genotype. Data are mean ± SD. *P < 0.05, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512