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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Fig. 3

Histopathological analysis. H&E staining of the histopathological sections of the liver, heart, kidneys, spleen, thymus, and lungs in the experimental groups. Scale bars: 100x (200 μm), 400x (50 μm). A IVD groups, B IV groups, and C histopathological findings after IVD administration in the different experimental groups. In the control group, the degenerated disc exhibited a loss of normal height and central NP, disorganization of the lamellar arrangement of the annulus fibrosus, remodeling, and thickening of the cartilaginous endplate. Histopathological evaluation of the treatment group (female and male subjects) in both genders showed a loss of normal disc height in these groups. Yellow arrow: disc prolapse; red arrow: AF degeneration; black arrow: thickening and remodeling of the CEP; thin back arrows: NP cell necrosis; green arrow: needle entry site. H&E: hematoxylin and eosin; IVD: intervertebral disc; IV: intravenous, NP: nucleus pulposus; AF: annulus fibrosus; CEP: cartilaginous endplate

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