Skip to main content

Table 4 Pooled hematological parameters (male and female) in the IVD groups for the study of subacute and subchronic toxicities of human BM-cMSCs

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Parameters

Subacute phase

Subchronic phase

Treatment group

Control

P value

Treatment group

Control

p value

Number of animals analyzed

11

12

12

12

WBCs (× 103/μl)

11.17 ± 3.46

11.07 ± 1.79

0.93

8.26 ± 1.26

8.26 ± 1.26

0.51

RBCs (× 106/μl)

5.91 ± 0.71

6.33 ± 0.69

0.17

6.42 ± .40

6.42 ± 0.40

0.22

HGB (g/dl)

11.08 ± 0.95

11.60 ± 1.07

0.23

12.31 ± .84

12.31 ± 0.84

1.0

HCT (%)

31.10 ± 3.05

31.46 ± 3.50

0.79

32.67 ± 2.03

32.67 ± 2.03

0.97

MCV (fl)

50.51 ± 1.91

50.20 ± 2.51

0.74

49.74 ± 1.14

49.74 ± 1.14

0.86

MCH (pg)

18.79 ± 1.54

17.60 ± 1.49

0.07

19.61 ± .85

19.61 ± .85

1.0

MCHC (g/dl)

36.64 ± 0.97

36.42 ± 0.97

0.59

38.90 ± 1.23

38.90 ± 1.23

0.90

PLT (103/μl)

485.74 ± 60.97

505.42 ± 45.0

0.38

542.08 ± 70.93

542.08 ± 70.93

0.59

RDW (%)

12.51 ± 1.24

12.35 ± 1.17

0.75

11.31 ± .53

11.31 ± 0.53

0.67

Reticulocytes (%)

1.86 ± 0.28

1.85 ± 0.21

0.25

1.08 ± 0.16

1.08 ± 0.16

0.91

  1. IVD intervertebral disc; BM-cMSC bone marrow-derived clonal mesenchymal stromal cells; WBCs white blood cells; RBCs red blood cells; HGB hemoglobin; HCT hematocrit; MCV mean corpuscular volume; MCH mean corpuscular hemoglobin; MCHC mean corpuscular hemoglobin concentration; PLT platelets; RDW-CV red blood cell distribution width coefficient variation. P ≤ 0.05 indicates statistical significance