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Table 4 Pooled hematological parameters (male and female) in the IVD groups for the study of subacute and subchronic toxicities of human BM-cMSCs

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Parameters Subacute phase Subchronic phase
Treatment group Control P value Treatment group Control p value
Number of animals analyzed 11 12 12 12
WBCs (× 103/μl) 11.17 ± 3.46 11.07 ± 1.79 0.93 8.26 ± 1.26 8.26 ± 1.26 0.51
RBCs (× 106/μl) 5.91 ± 0.71 6.33 ± 0.69 0.17 6.42 ± .40 6.42 ± 0.40 0.22
HGB (g/dl) 11.08 ± 0.95 11.60 ± 1.07 0.23 12.31 ± .84 12.31 ± 0.84 1.0
HCT (%) 31.10 ± 3.05 31.46 ± 3.50 0.79 32.67 ± 2.03 32.67 ± 2.03 0.97
MCV (fl) 50.51 ± 1.91 50.20 ± 2.51 0.74 49.74 ± 1.14 49.74 ± 1.14 0.86
MCH (pg) 18.79 ± 1.54 17.60 ± 1.49 0.07 19.61 ± .85 19.61 ± .85 1.0
MCHC (g/dl) 36.64 ± 0.97 36.42 ± 0.97 0.59 38.90 ± 1.23 38.90 ± 1.23 0.90
PLT (103/μl) 485.74 ± 60.97 505.42 ± 45.0 0.38 542.08 ± 70.93 542.08 ± 70.93 0.59
RDW (%) 12.51 ± 1.24 12.35 ± 1.17 0.75 11.31 ± .53 11.31 ± 0.53 0.67
Reticulocytes (%) 1.86 ± 0.28 1.85 ± 0.21 0.25 1.08 ± 0.16 1.08 ± 0.16 0.91
  1. IVD intervertebral disc; BM-cMSC bone marrow-derived clonal mesenchymal stromal cells; WBCs white blood cells; RBCs red blood cells; HGB hemoglobin; HCT hematocrit; MCV mean corpuscular volume; MCH mean corpuscular hemoglobin; MCHC mean corpuscular hemoglobin concentration; PLT platelets; RDW-CV red blood cell distribution width coefficient variation. P ≤ 0.05 indicates statistical significance