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Table 5 Pooled hematological parameters (male and female) in the IV groups for the study of subacute and subchronic toxicities of human BM-cMSCs

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Parameters

Subacute phase

Subchronic phase

Treatment group

Control

P value

Treatment group

Control

P value

Number of animals analyzed

12

12

12

11

WBCs (× 103/μl)

8.55 ± 2.12

8.23 ± 1.65

0.68

9.0 ± 1.96

8.03 ± 1.33

0.18

RBCs (× 106/μl)

6.50 ± 0.68

6.31 ± 0.62

0.49

6.41 ± 0.51

6.21 ± 0.53

0.38

HGB (g/dl)

12.56 ± 0.37

12.46 ± 0.74

0.68

12.52 ± 0.76

12.18 ± 0.50

0.22

HCT (%)

36.56 ± 1.05

34.62 ± 4.73

0.19

33.25 ± 2.48

32.63 ± 2.81

0.58

MCV (fl)

52.72 ± 4.03

52.18 ± 3.24

0.72

50.62 ± 1.77

50.24 ± 1.60

0.59

MCH (pg)

20.52 ± 1.28

20.12 ± 1.98

0.56

19.71 ± 1.02

19.78 ± 1.29

0.89

MCHC (g/dl)

37.15 ± 2.64

37.04 ± 2.36

0.91

38.94 ± 1.88

39.20 ± 1.68

0.73

PLT (103/μl)

472.16 ± 29.44

471.31 ± 43.55

0.95

531.50 ± 125.49

545.0 ± 110.63

0.78

RDW (%)

12.45 ± 1.01

12.65 ± 1.34

0.67

11.33 ± 0.92

11.03 ± 0.82

0.42

Reticulocytes (%)

0.97 ± 0.43

1.04 ± 0.54

0.74

1.10 ± 0.22

1.04 ± 0.03

0.39

  1. IV intravenous; BM-cMSC bone marrow-derived mesenchymal stromal cells; WBCs white blood cells; RBCs red blood cells; HGB hemoglobin; HCT hematocrit; MCV mean corpuscular volume; MCH mean corpuscular hemoglobin; MCHC mean corpuscular hemoglobin concentration; PLT platelets; RDW-CV red blood cell distribution width coefficient variation. P ≤ 0.05 indicates statistical significance