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Table 5 Pooled hematological parameters (male and female) in the IV groups for the study of subacute and subchronic toxicities of human BM-cMSCs

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Parameters Subacute phase Subchronic phase
Treatment group Control P value Treatment group Control P value
Number of animals analyzed 12 12 12 11
WBCs (× 103/μl) 8.55 ± 2.12 8.23 ± 1.65 0.68 9.0 ± 1.96 8.03 ± 1.33 0.18
RBCs (× 106/μl) 6.50 ± 0.68 6.31 ± 0.62 0.49 6.41 ± 0.51 6.21 ± 0.53 0.38
HGB (g/dl) 12.56 ± 0.37 12.46 ± 0.74 0.68 12.52 ± 0.76 12.18 ± 0.50 0.22
HCT (%) 36.56 ± 1.05 34.62 ± 4.73 0.19 33.25 ± 2.48 32.63 ± 2.81 0.58
MCV (fl) 52.72 ± 4.03 52.18 ± 3.24 0.72 50.62 ± 1.77 50.24 ± 1.60 0.59
MCH (pg) 20.52 ± 1.28 20.12 ± 1.98 0.56 19.71 ± 1.02 19.78 ± 1.29 0.89
MCHC (g/dl) 37.15 ± 2.64 37.04 ± 2.36 0.91 38.94 ± 1.88 39.20 ± 1.68 0.73
PLT (103/μl) 472.16 ± 29.44 471.31 ± 43.55 0.95 531.50 ± 125.49 545.0 ± 110.63 0.78
RDW (%) 12.45 ± 1.01 12.65 ± 1.34 0.67 11.33 ± 0.92 11.03 ± 0.82 0.42
Reticulocytes (%) 0.97 ± 0.43 1.04 ± 0.54 0.74 1.10 ± 0.22 1.04 ± 0.03 0.39
  1. IV intravenous; BM-cMSC bone marrow-derived mesenchymal stromal cells; WBCs white blood cells; RBCs red blood cells; HGB hemoglobin; HCT hematocrit; MCV mean corpuscular volume; MCH mean corpuscular hemoglobin; MCHC mean corpuscular hemoglobin concentration; PLT platelets; RDW-CV red blood cell distribution width coefficient variation. P ≤ 0.05 indicates statistical significance