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Table 6 Pooled biochemical parameters (male and female) in the IVD groups for the study of subacute and subchronic toxicities of human BM-cMSCs

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Parameters Subacute phase Subchronic phase
Treatment group Control P value Treatment group Control P value
Number of animals analyzed 11 12 12 12
Glucose (mg/dl) 144.50 ± 9.20 146.70 ± 13.80 0.66 118.5 ± 7.42 121.66 ± 6.82 0.3
Urea (mg/dl) 61.00 ± 6.94 57.16 ± 3.92 0.11 45.66 ± 4.11 46.0 ± 3.41 0.83
Cr (mg/dl) 0.60 ± 0.11 0.55 ± 0.12 0.34 0.68 ± 0.10 0.69 ± 0.12 0.77
ALT (U/l) 57.90 ± 12.08 59.25 ± 10.81 0.78 55.16 ± 6.13 55.08 ± 7.46 0.97
AST (U/l) 131.36 ± 42.01 138.58 ± 26.89 0.62 113.83 ± 11.59 119.41 ± 12.22 0.26
ALP (U/l) 769.54 ± 106.95 763.08 ± 91.82 0.87 303.91 ± 68.75 319.50 ± 60.06 0.56
Chol (mg/dl) 54.54 ± 7.78 60.83 ± 10.60 0.12 49.50 ± 9.86 48.58 ± 11.37 0.83
TG (mg/dl) 71.27 ± 23.27 71.16 ± 20.19 0.99 61.33 ± 13.95 58.00 ± 15.59 0.58
TP (g/dl) 5.57 ± 0.58 5.44 ± 0.69 0.63 6.39 ± 0.82 6.26 ± .43 0.64
Alb (g/dl) 3.08 ± 0.341 3.18 ± 0.30 0.5 3.12 ± 0.50 3.03 ± .40 0.63
TB (mg/dl) 0.15 ± 0.02 0.15 ± 0.03 0.58 0.22 ± 0.05 0.21 ± 0.05 0.75
DB (mg/dl) 0.08 ± 0.03 0.07 ± 0.02 0.53 0.12 ± 0.02 0.14 ± 0.02 0.09
P (mg/dl) 6.47 ± 1.08 6.41 ± 1.08 0.89 4.97 ± 0.61 5.05 ± .62 0.77
Ca (mg/dl) 8.50 ± 0.36 8.30 ± 0.40 0.25 7.85 ± 0.47 8.00 ± .54 0.50
Na (mEq/l) 140.9 ± 2.62 140.75 ± 3.16 0.89 138.50 ± 2.23 139.41 ± 3.17 0.42
K (mEq/l) 4.67 ± 0.82 5.23 ± 0.81 0.11 4.00 ± 0.28 4.00 ± 0.28 0.94
Cl (mEq/l) 108.45 ± 4.88 105.50 ± 4.31 0.13 103.58 ± 2.23 104.66 ± 1.87 0.21
HDL (mg/dl) 40.54 ± 2.62 41.41 ± 2.35 0.41 43.50 ± 2.06 42.91 ± 2.42 0.53
LDL (mg/dl) 33.36 ± 3.29 32.91 ± 3.47 0.75 34.50 ± 2.46 34.25 ± 2.66 0.81
PT (sec) 17.54 ± 1.34 17.70 ± 1.50 0.79 18.09 ± 0.88 18.45 ± 0.91 0.33
PTT (sec) 37.80 ± 4.97 36.32 ± 5.15 0.49 34.20 ± 3.55 34.47 ± 3.23 0.84
  1. BM-cMSC bone marrow-derived mesenchymal stromal cells; IVD intervertebral disc; Cr creatinine; ALT alanine aminotransferase; AST aspartate transaminase; ALP alkaline phosphatase; Chol cholesterol; TG triglycerides; TP total protein; Alb albumin; TB total bilirubin; DB direct bilirubin; P phosphorus; Ca calcium; Na sodium; K potassium; CL chloride; HDL high-density lipoprotein cholesterol; LDL low-density lipoprotein cholesterol; SD standard deviation. P ≤ 0.05 indicates statistical significance