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Table 6 Pooled biochemical parameters (male and female) in the IVD groups for the study of subacute and subchronic toxicities of human BM-cMSCs

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Parameters

Subacute phase

Subchronic phase

Treatment group

Control

P value

Treatment group

Control

P value

Number of animals analyzed

11

12

12

12

Glucose (mg/dl)

144.50 ± 9.20

146.70 ± 13.80

0.66

118.5 ± 7.42

121.66 ± 6.82

0.3

Urea (mg/dl)

61.00 ± 6.94

57.16 ± 3.92

0.11

45.66 ± 4.11

46.0 ± 3.41

0.83

Cr (mg/dl)

0.60 ± 0.11

0.55 ± 0.12

0.34

0.68 ± 0.10

0.69 ± 0.12

0.77

ALT (U/l)

57.90 ± 12.08

59.25 ± 10.81

0.78

55.16 ± 6.13

55.08 ± 7.46

0.97

AST (U/l)

131.36 ± 42.01

138.58 ± 26.89

0.62

113.83 ± 11.59

119.41 ± 12.22

0.26

ALP (U/l)

769.54 ± 106.95

763.08 ± 91.82

0.87

303.91 ± 68.75

319.50 ± 60.06

0.56

Chol (mg/dl)

54.54 ± 7.78

60.83 ± 10.60

0.12

49.50 ± 9.86

48.58 ± 11.37

0.83

TG (mg/dl)

71.27 ± 23.27

71.16 ± 20.19

0.99

61.33 ± 13.95

58.00 ± 15.59

0.58

TP (g/dl)

5.57 ± 0.58

5.44 ± 0.69

0.63

6.39 ± 0.82

6.26 ± .43

0.64

Alb (g/dl)

3.08 ± 0.341

3.18 ± 0.30

0.5

3.12 ± 0.50

3.03 ± .40

0.63

TB (mg/dl)

0.15 ± 0.02

0.15 ± 0.03

0.58

0.22 ± 0.05

0.21 ± 0.05

0.75

DB (mg/dl)

0.08 ± 0.03

0.07 ± 0.02

0.53

0.12 ± 0.02

0.14 ± 0.02

0.09

P (mg/dl)

6.47 ± 1.08

6.41 ± 1.08

0.89

4.97 ± 0.61

5.05 ± .62

0.77

Ca (mg/dl)

8.50 ± 0.36

8.30 ± 0.40

0.25

7.85 ± 0.47

8.00 ± .54

0.50

Na (mEq/l)

140.9 ± 2.62

140.75 ± 3.16

0.89

138.50 ± 2.23

139.41 ± 3.17

0.42

K (mEq/l)

4.67 ± 0.82

5.23 ± 0.81

0.11

4.00 ± 0.28

4.00 ± 0.28

0.94

Cl (mEq/l)

108.45 ± 4.88

105.50 ± 4.31

0.13

103.58 ± 2.23

104.66 ± 1.87

0.21

HDL (mg/dl)

40.54 ± 2.62

41.41 ± 2.35

0.41

43.50 ± 2.06

42.91 ± 2.42

0.53

LDL (mg/dl)

33.36 ± 3.29

32.91 ± 3.47

0.75

34.50 ± 2.46

34.25 ± 2.66

0.81

PT (sec)

17.54 ± 1.34

17.70 ± 1.50

0.79

18.09 ± 0.88

18.45 ± 0.91

0.33

PTT (sec)

37.80 ± 4.97

36.32 ± 5.15

0.49

34.20 ± 3.55

34.47 ± 3.23

0.84

  1. BM-cMSC bone marrow-derived mesenchymal stromal cells; IVD intervertebral disc; Cr creatinine; ALT alanine aminotransferase; AST aspartate transaminase; ALP alkaline phosphatase; Chol cholesterol; TG triglycerides; TP total protein; Alb albumin; TB total bilirubin; DB direct bilirubin; P phosphorus; Ca calcium; Na sodium; K potassium; CL chloride; HDL high-density lipoprotein cholesterol; LDL low-density lipoprotein cholesterol; SD standard deviation. P ≤ 0.05 indicates statistical significance