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Table 7 Pooled biochemical parameters (male and female) in the IV groups for the study of subacute and subchronic toxicities of human BM-cMSCs

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Parameters Subacute phase Subchronic phase
Treatment group Control P value Treatment group Control P value
Number of animals analyzed 12 12 12 11
Glucose (mg/dl) 145.91 ± 7.94 151.43 ± 11.68 0.19 134.33 ± 11.93 128.81 ± 13.36 0.30
Urea (mg/dl) 54.08 ± 4.96 51.08 ± 4.87 0.14 48.00 ± 5.57 49.27 ± 4.45 0.55
Cr (mg/dl) 0.65 ± 0.10 0.60 ± 0.10 0.35 0.70 ± 0.09 0.76 ± 0.11 0.15
ALT (U/l) 49.25 ± 5.18 51.08 ± 6.50 0.45 56.58 ± 6.25 55.09 ± 6.26 0.57
AST (U/l) 103.50 ± 9.11 102.91 ± 10.76 0.88 101.66 ± 8.65 102.36 ± 7.07 0.83
ALP (U/l) 519.08 ± 174.52 584.44 ± 149.31 0.33 365.91 ± 109.15 324.0 ± 75.54 0.30
Chol (mg/dl) 54.16 ± 7.35 53.75 ± 7.74 0.89 51.33 ± 9.80 51.09 ± 9.54 0.95
TG (mg/dl) 49.91 ± 17.35 54.83 ± 20.89 0.53 70.58 ± 19.03 64.81 ± 17.85 0.46
TP (g/dl) 6.01 ± .59 6.08 ± .74 0.81 6.21 ± .59 6.36 ± .66 0.57
Alb (g/dl) 3.42 ± .24 3.40 ± .21 0.83 3.37 ± .26 3.38 ± .37 0.96
TB (mg/dl) 0.76 ± 0.22 0.62 ± 0.18 0.09 0.18 ± 0.02 0.18 ± 0.03 0.65
DB (mg/dl) 0.15 ± 0.05 0.13 ± 0.04 0.26 0.10 ± 0.02 0.11 ± 0.02 0.50
P (mg/dl) 6.58 ± 0.79 7.19 ± 0.97 0.10 5.94 ± 0.29 5.99 ± 0.20 0.65
Ca (mg/dl) 8.35 ± 0.17 8.23 ± 0.31 0.27 8.09 ± 1.03 8.04 ± 0.51 0.89
Na (mEq/l) 140.66 ± 2.05 140.50 ± 2.11 0.84 139.16 ± 2.16 139.45 ± 1.80 0.73
K (mEq/l) 3.91 ± 0.22 4.05 ± 0.56 0.46 3.90 ± 0.27 3.65 ± 0.44 0.12
Cl (mEq/l) 107.66 ± 4.79 106.91 ± 5.35 0.72 103.83 ± 3.06 103.27 ± 3.37 0.68
HDL (mg/dl) 41.25 ± 2.83 41.08 ± 3.08 0.89 42.33 ± 2.96 41.54 ± 3.11 0.54
LDL (mg/dl) 33.00 ± 3.46 33.91 ± 2.93 0.49 33.00 ± 3.33 31.81 ± 2.78 0.36
PT (s) 17.97 ± 1.40 17.81 ± 0.90 0.74 17.95 ± 0.99 17.94 ± 0.96 0.97
PTT (s) 36.80 ± 2.76 35.97 ± 4.46 0.59 33.94 ± 2.79 33.32 ± 3.12 0.62
  1. BM-cMSC bone marrow-derived mesenchymal stromal cells; IV intravenous; Cr creatinine; ALT alanine aminotransferase; AST aspartate transaminase; ALP alkaline phosphatase; Chol cholesterol; TG triglycerides; TP total protein; Alb albumin; TB total bilirubin; DB direct bilirubin; P phosphorus; Ca calcium; Na sodium; K potassium; CL chloride; HDL high-density lipoprotein cholesterol; LDL low-density lipoprotein cholesterol; SD standard deviation. P ≤ 0.05 indicates statistical significance