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Table 7 Pooled biochemical parameters (male and female) in the IV groups for the study of subacute and subchronic toxicities of human BM-cMSCs

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Parameters

Subacute phase

Subchronic phase

Treatment group

Control

P value

Treatment group

Control

P value

Number of animals analyzed

12

12

12

11

Glucose (mg/dl)

145.91 ± 7.94

151.43 ± 11.68

0.19

134.33 ± 11.93

128.81 ± 13.36

0.30

Urea (mg/dl)

54.08 ± 4.96

51.08 ± 4.87

0.14

48.00 ± 5.57

49.27 ± 4.45

0.55

Cr (mg/dl)

0.65 ± 0.10

0.60 ± 0.10

0.35

0.70 ± 0.09

0.76 ± 0.11

0.15

ALT (U/l)

49.25 ± 5.18

51.08 ± 6.50

0.45

56.58 ± 6.25

55.09 ± 6.26

0.57

AST (U/l)

103.50 ± 9.11

102.91 ± 10.76

0.88

101.66 ± 8.65

102.36 ± 7.07

0.83

ALP (U/l)

519.08 ± 174.52

584.44 ± 149.31

0.33

365.91 ± 109.15

324.0 ± 75.54

0.30

Chol (mg/dl)

54.16 ± 7.35

53.75 ± 7.74

0.89

51.33 ± 9.80

51.09 ± 9.54

0.95

TG (mg/dl)

49.91 ± 17.35

54.83 ± 20.89

0.53

70.58 ± 19.03

64.81 ± 17.85

0.46

TP (g/dl)

6.01 ± .59

6.08 ± .74

0.81

6.21 ± .59

6.36 ± .66

0.57

Alb (g/dl)

3.42 ± .24

3.40 ± .21

0.83

3.37 ± .26

3.38 ± .37

0.96

TB (mg/dl)

0.76 ± 0.22

0.62 ± 0.18

0.09

0.18 ± 0.02

0.18 ± 0.03

0.65

DB (mg/dl)

0.15 ± 0.05

0.13 ± 0.04

0.26

0.10 ± 0.02

0.11 ± 0.02

0.50

P (mg/dl)

6.58 ± 0.79

7.19 ± 0.97

0.10

5.94 ± 0.29

5.99 ± 0.20

0.65

Ca (mg/dl)

8.35 ± 0.17

8.23 ± 0.31

0.27

8.09 ± 1.03

8.04 ± 0.51

0.89

Na (mEq/l)

140.66 ± 2.05

140.50 ± 2.11

0.84

139.16 ± 2.16

139.45 ± 1.80

0.73

K (mEq/l)

3.91 ± 0.22

4.05 ± 0.56

0.46

3.90 ± 0.27

3.65 ± 0.44

0.12

Cl (mEq/l)

107.66 ± 4.79

106.91 ± 5.35

0.72

103.83 ± 3.06

103.27 ± 3.37

0.68

HDL (mg/dl)

41.25 ± 2.83

41.08 ± 3.08

0.89

42.33 ± 2.96

41.54 ± 3.11

0.54

LDL (mg/dl)

33.00 ± 3.46

33.91 ± 2.93

0.49

33.00 ± 3.33

31.81 ± 2.78

0.36

PT (s)

17.97 ± 1.40

17.81 ± 0.90

0.74

17.95 ± 0.99

17.94 ± 0.96

0.97

PTT (s)

36.80 ± 2.76

35.97 ± 4.46

0.59

33.94 ± 2.79

33.32 ± 3.12

0.62

  1. BM-cMSC bone marrow-derived mesenchymal stromal cells; IV intravenous; Cr creatinine; ALT alanine aminotransferase; AST aspartate transaminase; ALP alkaline phosphatase; Chol cholesterol; TG triglycerides; TP total protein; Alb albumin; TB total bilirubin; DB direct bilirubin; P phosphorus; Ca calcium; Na sodium; K potassium; CL chloride; HDL high-density lipoprotein cholesterol; LDL low-density lipoprotein cholesterol; SD standard deviation. P ≤ 0.05 indicates statistical significance