Fig. 1From: Characteristics of the cancer stem cell niche and therapeutic strategiesCSC niche in solid tumor. CSC niche has a complex microenvironment, it usually includes cancer cells, cancer stem cells, stromal cells, endothelial cells, fibroblasts, cancer-associated fibroblasts, ECM, exosomes and intrinsic factors. These components together contribute to the CSC renewal and maintain tumor malignancyBack to article page