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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice

Fig. 3

hAMSCs inhibit HSCs activation in liver fibrosis mice through paracrine mechanisms. A, B Immunohistochemical staining of α-SMA and TGF-β expressing cells in liver tissues of control, PBS, and hAMSCs group. C The protein expression levels of α-SMA and TGF-β in liver tissues of different groups were analyzed by western blot. D Quantitative analysis of the expression of α-SMA and TGF-β in liver tissues as in C. E The liver tissues sections of different groups were co-stained with MAB1281 and CD90 and imaged by confocal microscope. *P < 0.05, *P < 0.01, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512