Fig. 1

The safety evaluation of HucMSCs in vivo. A Representative images of subcutaneous tumor formation between HucMSC and A549 groups on day 60. B The survival curves of HucMSC and A549 groups were observed for 120 days. *p < 0.05 versus A549 group. C Representative H&E immunohistochemical photos of the lung, liver, kidney and spleen on day 28. Scale bar = 100 µm. D The AST, ALT, Cr, LDH, CK, CK-MB levels in serum were measured in different groups on day 7 or 28. ns, no significant difference versus MI-N.S group. MI, myocardiac infarct; N.S, normal saline; HucMSCs, Human umbilical cord-derived mesenchymal stem cells; AST, aspartate transaminase; ALT, alanine aminotransferase; Cr, Creatine; LDH, Lactate dehydrogenase, CK, Creatine kinase; CK-MB, Creatine kinase isoenzyme