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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: The therapeutic effects of human embryonic stem cells-derived immunity-and-matrix regulatory cells on membranous nephropathy

Fig. 3

Analysis of glomerular basement membrane. Electron-dense deposits in the subepithelial area (red asterisks) and the podocyte foot processes diffusive fusion (blue asterisks) on electron microscopy (a1, × 10,000). The electron-dense deposits and the podocyte foot processes fusion (a2, a3) were alleviated, in both the high-dose IMRC group (6 × 106 cells) and the low-dose IMRC group (3 × 106 cells). No obvious kidney injury was observed in negative controls (a4). Quantitative analysis of podocyte foot process width (FPW) and glomerular basement membrane thickness. The foot process width (b) in low-dose IMRC group (3 × 106 cells, T1, n = 4) and that in high-dose IMRC group (6 × 106 cells, T2, n = 4) was significantly decreased at week 7, and was comparable to that in negative controls (n = 4). The thickness of glomerular basement membrane (c) in high-dose IMRC group and low-dose IMRC group was significantly decreased at week 7, and was comparable to that in negative controls. *P < 0.05; **P < 0.01; ***P < 0.001

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