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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Activin B-activated Cdc42 signaling plays a key role in regulating adipose-derived mesenchymal stem cells-mediated skin wound healing

Fig. 6

Cdc42 deletion in ADSCs exhibits a distinct transcriptional signature. A Heatmap showing differentially expressed genes (DEGs) between ADSCs (Con) and ADSCs transduced with Cdc42N17. There were 216 upregulated and 266 downregulated DEGs in ADSCs (Cdc42N17), respectively, and were subjected to Kyoto Encyclopedia of Genes and Genomes pathways enriched (KEGG) and gene ontology (GO) analysis. B, C showing the top 15 enrich pathways in upregulated and downregulated DEGs, while D showing the top 15 biological processes in upregulated and downregulated DEGs. E Selected gene expression in some of the GO biological processes. F qPCR analysis of relative expression level of Cdkn2b, Wnt11, Pdgfb, Iqgap3, Racgap1 and Cd248 in ADSCs (Cdc42N17). All values are expressed as mean ± SD from three independent repeats. *P < 0.05

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