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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Intravenously transplanted mesenchymal stromal cells: a new endocrine reservoir for cardioprotection

Fig. 8

Schematic illustration of the role of intravenously injected MSCs on cardioprotection. Intravenously transplanted mesenchymal stromal cells (MSCs), as an endocrine reservoir, released functional extracellular vesicles (EVs) from the lung to the heart continuously and gradually. Specific component in MSCs-derived EVs once delivered to injured myocardium is identified to alleviate doxorubicin (Dox)-induced cardiotoxicity through suppressing endoplasmic reticulum (ER) stress-induced cardiomyocyte apoptosis

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