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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Mesenchymal stromal cells pretreated with proinflammatory cytokines enhance skin wound healing via IL-6-dependent M2 polarization

Fig. 3

IL-6 secreted by IT MSCs is a major cytokine in remodeling the M1 phenotype to the M2 phenotype. Macrophages were prestimulated with 200 ng/ml LPS for 2 h to polarize them toward the M1 phenotype followed by the addition of supernatants from each group of stem cells and continued coincubation for 24 h. A, B The percentage of CD206- and Arg-1-positive as well as CD86- and iNOS-positive cells in M1 phenotype macrophages after treatment with the above supernatant groups according to flow cytometry. Data are representative of three independent experiments. *P < 0.05; **P < 0.001; ***P < 0.0001

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