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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stromal cells pretreated with proinflammatory cytokines enhance skin wound healing via IL-6-dependent M2 polarization

Fig. 5

IL-6 secreted by IT MSCs promotes polarization of M2 macrophages via an IL-6-dependent signaling pathway. A Western blot analysis of IL-4Rα, STAT6, p-STAT6, PPAR-γ, STAT3, and p-STAT3 expression. B–E Corresponding histogram protein levels or ratios of IL-4Rα, p-STAT6/STAT6, PPAR-γ, and p-STAT3/STAT3. F IL-4Rα and PPAR-γ gene expression of wound tissue on day 3 in vivo, n = 4 mice for each group. Data are representative of four independent experiments. *P < 0.05; **P < 0.001, and ***P < 0.0001

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Stem Cell Research & Therapy

ISSN: 1757-6512