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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Mesenchymal stromal cells pretreated with proinflammatory cytokines enhance skin wound healing via IL-6-dependent M2 polarization

Fig. 7

IL-6 secreted by IT MSCs increases the percentage of M2 macrophages via an IL-6-dependent signaling pathway in the local wounds of mice. A Immunofluorescence staining of CD86 (green), CD163 (red), and DAPI (blue) at the wound site after systemic injection of the DMEM, S-siNC-MSCs, S-siNC-IT MSCs, S-siIL-6-IT MSCs, S-siIL-6-IT MSCs-recIL-6 at day 3. B Corresponding histogram percentage of M1 and M2 in the local wounds. The numbers of stained nuclei were counted in three high-power fields per well under fluorescence microscopy. Data are representative of four independent experiments. n = 4 mice for each group, Scale bar = 20 μm, *P < 0.05; **P < 0.001, and ***P < 0.0001

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