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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Mesenchymal stromal cells pretreated with proinflammatory cytokines enhance skin wound healing via IL-6-dependent M2 polarization

Fig. 8

IT MSCs-derived IL-6 promotes angiogenesis at local wounds. A, C Cutaneous wounds on days 3 and 7 were stained with CD31 immunohistochemistry, and micrographs were acquired. Red arrows indicate blood vessels. B, D The number of blood vessels in each section was counted at the indicated time points, and the results are presented as the number of blood vessels per mm.2. CD31 positive area (%) was also detected by ImageJ. The numbers of stained CD31 were counted in four high-power fields per well under microscopy. Data are representative of four independent experiments. n = 4 mice for each group, Scale bar = 100 μm. *P < 0.05; **P < 0.001, and ***P < 0.0001

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