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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells

Fig. 1

HFD-induced obesity caused systemic inflammation. A Mice were fed with NCD (11.6% kcal fat) or HFD (60% kcal fat) for 12 weeks, and body weights were measured weekly. HFD significantly induced body weight gain compared with NCD feeding. B-C The weights of liver tissues and liver/body weight ratio were obviously increased by HFD feeding. D-E The fat gains and fat/body weight ratio of HFD group were significantly increased compared with NCD group. F Oil Red O staining of liver sections was carried out. HFD feeding led to obvious lipid droplet accumulation. G The H&E of epididymal white adipose tissues. H The expressions of inflammatory cytokines were revealed by RT-PCR. I The phosphorylations of MAPK p38, ERK1/2, and JNK in visceral white adipose tissues were detected by western blot analysis. J-L The quantified data of MAPK p38, ERK1/2 and JNK phosphorylation were analyzed by Image J, respectively. (N = 6 per group). (* p < 0.05; ** p < 0.01)

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