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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells

Fig. 3

MSCs and IL10-MSCs reduced HFD-induced obesity.A Mice were fed with NCD or HFD for 12 weeks, and body weights were measured weekly. Both MSCs and IL10-MSCs treatments could markedly alleviate the HFD-induced obesity, and IL10-MSCs had a better obesity inhibition. B-C The weights of subcutaneous and epididymal white adipose tissues were assayed. MSCs and IL10-MSCs significantly inhibited the fat gains and fat/body weight ratio induced by HFD, and the latter had better effect. D-E MSCs and IL10-MSCs treatments inhabited the weights of liver tissues and liver/body weight ratio induced by HFD feeding. F Food intake was assayed according to metabolic cage analysis, and there were no significant differences among 4 groups. G-H The O2 consumption and CO2 release were evaluated in mice among 4 groups. HFD feeding reduced O2 consumptions and CO2 release, which were relieved by MSCs and IL10-MSCs treatment. I RER value was assayed and there were no significant differences among 4 groups. (N = 6 per group). (* p < 0.05; ** p < 0.01; ***p < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512