Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells

Fig. 4

IL10-MSCs had better protective effect on lipid metabolic syndrome and liver function in HFD-fed mice (N = 6 in each group). A The effects of MSCs and IL10-MSCs treatment on serum lipid profiles in HFD-fed mice. B The serum levels of ALT and AST in four groups. MSCs and IL10-MSCs both decreased the high levels of ALT and AST induced by HFD feeding, latter had better decrease. C IL10-MSCs treatment clearly decreased the HFD-induced high level of hepatic TG. D-E H&E and Oil Red O staining of liver sections were observed. HFD feeding led to obvious lipid droplets accumulation and more white vacuoles compared with NCD. MSCs and IL10-MSCs administrations remarkably lessened vacuoles and lipid droplets in liver. Moreover, IL10-MSCs had better protective effect on decreasing vacuoles and lipid droplets accumulation. (N = 6 mice per group).* p < 0.05; ** p < 0.01; ***p < 0.001

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512