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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells

Fig. 5

IL10-MSCs improved glucose tolerance and insulin sensitivity in HFD-fed mice. A HFD feeding increased the fasting blood glucose in mice, which were markedly alleviated by MSCs and IL10-MSCs treatments, especially latter. B The curve of blood glucose concentration at indicated time points after intraperitoneal injection of glucose. C Summed GTT was evaluated according to AUC of Fig. 5B. HFD feeding increased the blood glucose levels, which was reduced by MSCs and IL10-MSCs treatments. D The curve of blood glucose level at indicated time points after intraperitoneal injection of insulin.E ITT was evaluated based on AUC of Fig. 5D. (N = 6 mice per group) (* p < 0.05; ** p < 0.01; ***p < 0.001)

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