Fig. 3

The brain MRI findings for assessment of the brain hemorrhagic volume (BHV) by 16 h and day 28 after intracranial hemorrhage (ICH) induction procedure. A–D Illustrating the brain MRI finding by 16 h after ICH induction (red dotted line area). E Analytical result of BHV, *versus †, p < 0.001. F–I Illustrating the brain MRI finding by day 28 after ICH induction (red dotted line area). J Analytical result of BHV, *versus other groups with different symbols (†, ‡, §), p < 0.001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 4 for each group). Symbols [(*, †, ‡, §) indicate significance (at 0.05 level). IA = intra-carotid arterial administration; IV intravenous (i.e., tail vein) administration; SC = sham control; ICH = intracranial hemorrhage; Ir-MNa-hUC-MSC = ironic magnetic nanoparticles/human umbilical cord-derived mesenchymal stem cells; MRI = magnetic resonance imaging