Fig. 4

The hUC-MSCs treatment effectively suppressed inflammatory reaction and generation of oxidative stress in brain by day 28 after ICH induction. A Protein expression of tumor necrosis factor (TNF)-α, *versus other groups with different symbols (†, ‡, §), p < 0.0001. B Protein expression of matrix metalloproteinase (MMP)-9, *versus other groups with different symbols (†, ‡, §), p < 0.0001. C Protein expression of interleukin (IL)-1ß, *versus other groups with different symbols (†, ‡, §), p < 0.0001. D Protein expression of inducible nitric oxide synthase (iNOS), *versus other groups with different symbols (†, ‡, §), p < 0.0001. E Protein expression of NOX-1, *versus other groups with different symbols (†, ‡, §), p < 0.0001. F Protein expression of NOX-2, *versus other groups with different symbols (†, ‡, §), p < 0.0001. G The oxidized protein expression, *versus other groups with different symbols (†, ‡, §), p < 0.0001 (Note: the left and right lanes shown on the upper panel represent protein molecular weight marker and control oxidized molecular protein standard, respectively). M.W. = molecular weight; DNP = 1–3 dinitrophenylhydrazone. H Protein expression of interleukin (IL)-10, *versus other groups with different symbols (†, ‡, §), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols [(*, †, ‡, §) indicate significance (at 0.05 level). IA = intra-carotid arterial administration; IV intravenous (i.e., tail vein) administration; SC = sham control; ICH = intracranial hemorrhage; Ir-MNa-hUC-MSC = ironic magnetic nanoparticles/human umbilical cord-derived mesenchymal stem cells