Fig. 5

The hUC-MSCs treatment effectively downregulated apoptosis, fibrosis and generation of oxidative stress in brain by day 28 after ICH induction. A Protein expressions of caspase-3 (Csp3), *versus other groups with different symbols (†, ‡, §), p < 0.0001. B Protein expression of mitochondrial (Mit)-Bax, *versus other groups with different symbols (†, ‡, §), p < 0.0001. C Protein expression of cleaved poly [ADP-ribose] polymerase (c-PARP), *versus other groups with different symbols (†, ‡, §), p < 0.0001. D Protein expression of transforming growth factor (TGF)-ß, *versus other groups with different symbols (†, ‡, §), p < 0.0001. E Protein expression of phosphorylated (p)- Smad3, *versus other groups with different symbols (†, ‡, §), p < 0.0001. F Protein expression of cytosolic cytochrome C (cyto-CytC), *versus other groups with different symbols (†, ‡, §), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols [(*, †, ‡, §) indicate significance (at 0.05 level). IA = intra-carotid arterial administration; IV intravenous (i.e., tail vein) administration; SC = sham control; ICH = intracranial hemorrhage; Ir-MNa-hUC-MSC = ironic magnetic nanoparticles/human umbilical cord-derived mesenchymal stem cells