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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: SNTA1-deficient human cardiomyocytes demonstrate hypertrophic phenotype and calcium handling disorder

Fig. 8

Early application of ranolazine improving the calcium handling of KO-cardiomyocytes. A The left panel: The representative line-scan image of the KO-cardiomyocytes and KO + R (KO-cardiomyocytes treated with 10 μM ranolazine) stained with Fluo-4 on the 20th day of cardiac differentiation. The right panel: Calcium transient profile derived from the left panel. BE. Quantification of time to peak, peak, contraction duration, and beating rate in KO-cardiomyocytes and KO + R, n = 6. **P < 0.01; ****P < 0.0001; unpaired two-sided Student’s t test. F Contractility graph of KO-cardiomyocytes and KO + R (KO-cardiomyocytes treated with 10 μM ranolazine). G Quantification of the panel F. n = 3 independent experiments. *P < 0.05. Unpaired two-sided Student’s t test

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