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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA

Fig. 7

Schematic diagram of KAP1 phosphorylation during cerebral I/R involved in endogenous NSCs proliferation and apoptosis is summarized. Simulated p-KAP1 promoted the proliferation of endogenous neural stem cells (NSCs) and the expression of PCNA in cerebral I/R. Simulated p-KAP1 bound to PCNA, inhibiting CUL4A-mediated ubiquitination degradation to PCNA. This finding suggests that targeting the KAP-1/PCNA signaling pathway could enhance the neurogenesis of endogenous NSCs in the management of brain diseases

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Stem Cell Research & Therapy

ISSN: 1757-6512