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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: TSG-6 released from adipose stem cells-derived small extracellular vesicle protects against spinal cord ischemia reperfusion injury by inhibiting endoplasmic reticulum stress

Fig. 3

ADSC-sEVs treatment improved functional recovery and attenuated neuronal apoptosis following SCIRI. a Basso Mouse Scale (BMS) values at different times after SCIRI. b The inclined plane test at different times after SCIRI. c Representative images of the footprint assay performed 28 days after SCIRI. d Photographs of the swimming test conducted 28 days after SCIRI and statistical analysis of the Louisville Swim Scale. e Dil-sEVs accumulated in the injury area of spinal cord. f Analysis of apoptosis of neurons following SCIRI with the TUNEL assay. g Quantification of apoptosis rate in each experimental group. h Expression of apoptosis-related proteins following SCIRI as determined using Western blotting assay. i Relative expression levels of apoptosis-related proteins normalized to GAPDH. *p < 0.05 compared with the Sham group, #p < 0.05 compared with the SCIRI group

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