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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: TSG-6 released from adipose stem cells-derived small extracellular vesicle protects against spinal cord ischemia reperfusion injury by inhibiting endoplasmic reticulum stress

Fig. 6

ADSC-sEVs reduce apoptosis and BSCB disruption by suppressing ER stress. a Results of the TUNEL assay showing the number of apoptotic neurons induced by OGD/R with or without ADSC-sEVs and TM pretreatment. b Quantitative estimation of the apoptotic rate in each group. c Results of Annexin V-FITC/PI double staining as analyzed by flow cytometry. d Quantitative estimation of the apoptotic rate by flow cytometry. e Expression of apoptosis-related and tight junction proteins as determined by Western blotting analysis. f Western blotting analysis of ER stress-related proteins. g–j Relative expression levels of apoptosis, ER stress-related proteins, and tight junction proteins normalized to GAPDH. *p < 0.05 compared with the OGD/R group, #p < 0.05 compared with the ADSC-sEVs group

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Stem Cell Research & Therapy

ISSN: 1757-6512