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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: TSG-6 released from adipose stem cells-derived small extracellular vesicle protects against spinal cord ischemia reperfusion injury by inhibiting endoplasmic reticulum stress

Fig. 8

Overexpression of TSG-6 enhanced the protective effect of ADSC-sEVs following SCIRI. a TUNEL staining was conducted to measure apoptosis rate in each group. b Quantitative estimation of the apoptotic rate in each group. c Representative images showing double immunofluorescence of ZO-1 and CD31. d Quantification of the content of Evans blue in the spinal cord tissues. e Quantification of the fluorescence intensity of Evans blue. f Representative images of EB extravasation in the spinal cord sections. g, h Expression of apoptosis-related and tight junction proteins in each experimental group as determined by Western blotting assay. i, j Relative expression levels of apoptosis-related and tight junction proteins normalized to GAPDH. *p < 0.05 compared with the SCIRI group, #p < 0.05 compared with the Lenti-Ctrl-sEVs group

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Stem Cell Research & Therapy

ISSN: 1757-6512