From: Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update
References | Drug delivery route | Number of cells/exosomes | Type of ICH model Rat | Sample Size | Treatment Day after ICH | Earliest effective time (post ICH) | Behavioral recovery |
---|---|---|---|---|---|---|---|
Nonaka et al. [61] | Intraventricular | 1 × 105 ESCs | Rat Col VII | Sham 5 Treatment 10 | 7 d | NA | NA |
Chen et al. [62] | Intraventricular | 2–4 × 105 AD-MSCs | Rat Col IV | Control 40 Treatment 40 | 2 d | 3 d | Zea Longa 5-grade scale↑ |
Cui et al. [63] | Intravenous | 5 × 106 MSCs | Rat ABI | Control 15 Treatment 15 | 1 h and 24 h | 3 d | NSS↓ |
Wang et al. [38] | Intravenous | 1 × 106 MSCs | Rat ABI | Sham 12 Control 24 Treatment 24 | NA | 14 d | mNSS↓ MLPT scores↓ |
Chen et al. [39] | Intravenous | 5 × 106 MSCs | Rat Col IV | NA | 2 h | 3 d | mNSS↓ |
Wang et al. [42] | Intravenous | 1 × 106 MSCs | Rat Col VII | Control 6 treatment6 | 1 h | 7 d | mNSS↓ |
References | Drug delivery route | Number of cells/exosomes | Type of ICH model Rat | Sample Size | Treatment Day after ICH | Earliest effective time (post ICH) | Behavioral recovery |
---|---|---|---|---|---|---|---|
Seyfried et al. [52] | Intravenous | 0.5–1 × 106 MSCs | Rat ABI | Control 9 Treatment 18 | 24 h | 7 d | mNSS↓ corner-turn test↑ |
Nan et al. [57] | Intravenous | 2.4–3.2 × 106 MSCs | Rat Col VII | NA | 24 h | 7 d | limb-placement tests↑ stepping tests↑ body-swing tests↑ |
Yang et al. [64] | Intravenous | 1 × 106 AD-MSCs | Rat Col VII | Control 6 Treatment 9 | 24 h | 7 d | mNSS↓ |
Kim et al. [65] | Intravenous | 3 × 106 AD-MSCs | Rat Col VII | Control 16 Treatment 16 | 24 h | 28 d | MLPT scores↓ |
Jeong et al. [66] | Intravenous | 5 × 106 NSCs | Rat Col V | Control 13 Treatment 12 | 24 h | 14 d | rotarod test ↑ MLPT scores ↓ |
Vaquero et al. [67] | Intracerebral | 5 × 106 MSCs | Rat Col V | Control 20 Treatment 20 | 2 m | 4 m | rotarod tests↑ VTB tests↑ |
Bao et al. [68] | Intracerebral | 2 × 105 MSCs | Rat Col VII | Control 67 Treatment 65 | 24 h | 3 d | mNSS↓ |
References | Drug delivery route | Number of cells/exosomes | Type of ICH model Rat | Sample Size | Treatment day after ICH | Earliest effective time (post ICH) | Behavioral recovery |
---|---|---|---|---|---|---|---|
Liang et al. [69] | Intracerebral | 1 × 106 MSCs | Rat Col IV | Sham 8 Control 16 Treatment 16 | 24 h | 7 d | MLPT scores ↓ vibrissae-elicited forelimb-placing test↑ |
Otero et al. [70] | Intracerebral | 2 × 106 MSCs | Rat Col IV | Control 48 Treatment 48 | 2 h | NA | NA |
Yang et al. [71] | Intracerebral | 5 × 105 MSCs | Rat Col I | Control 10 Treatment20 | 3 d | 7 d | mNSS↓ |
Otero et al. [72] | Intracerebral | 2 × 106 MSCs | Rat Col IV | Control 10 Treatment10 | 3 d | 3 w | mNSS↓ Rotarod test↑ |
Otero et al. [73] | Intracerebral | 5 × 106 MSCs | Rat Col IV | Control 10 Treatment 10 | 2 m | 3 m | mNSS↓ Rotarod tests↑ VTB tests↑ locomotor activity↑ |
Feng et al. [74] | Intracerebral | 1–5 × 106 MSCs | Monkey ABI | Control 8 Treatment16 | 1 w or 4 w | 2 w or 5 w | Neurologic deficit scores↓ |
References | Drug delivery route | Number of cells/exosomes | Type of ICH Model Rat | Sample Size | Treatment day after ICH | Earliest effective time (post ICH) | Behavioral recovery |
---|---|---|---|---|---|---|---|
Nagai et al. [75] | Intracerebral | 2 × 105 MSCs | Rat Col VII | Control 4 Treatment 14 | 7 d | 8 d | Rotarod test↑ |
Seyfried et al. [76] | Intracerebral | 3, 5 and 8 × 106 MSCs | Rat ABI | Control 27 Treatment 27 | 24 h | 7 d | mNSS↓ corner-turn test↑ |
Zhang et al. [77] | Intracerebral | 1 × 105 MSCs | Rat Col IV | Control 60 Treatment 60 | 6 h | 24 h | mNSS↓ |
Gao et al. [78] | Intracerebral | 5 × 105 NSCs | Rat Col IV | Sham 20 Control 48 Treatment 26 | 3 h | 3 d | mNSS↓ |
Wakai et al. [79] | Intracerebral | 1 × 105 NSCs | Mouse ABI | NA | 3 d | 21 d | Cylinder tests↑ corner-turn tests↑ |
Wang et al. [80] | Intracerebral | 1 × 106 NSCs | Rat Col VII | Control 26 Treatment 13 | 3 d | 24 d | MLPT scores↓ |
Lee et al. [81] | Intracerebral | 2 × 105 NSCs | Mouse Col IV | Control 28 Treatment 61 | 7 d | 8 d | Rotarod test↑ MLPT scores↓ |
References | Drug delivery route | Number of cells/exosomes | Type of ICH Model Rat | Sample Size | Treatment day after ICH | Earliest effective time (post ICH) | Behavioral recovery |
---|---|---|---|---|---|---|---|
Lee et al. [82] | Intracerebral | 2 × 105 NSCs | Mouse Col IV | Control 20 Treatment 18 | 7 d | 5 w | Rotarod test↑ MLPT scores↓ |
Lee et al. [83] | Intracerebral | 2 × 105 NSCs | Mouse Col IV | Control 18 Treatment 39 | 7 d | 8 d | Rotarod test↑ MLPT scores↓ |
Lee et al. [84] | Intracerebral | 2 × 105 NSCs | Mouse Col VII | Control 30 Treatment 31 | 7 d | 21 d | Rotarod test↑ MLPT scores↓ |
Lee et al. [85] | Intracerebral | 2 × 105 NSCs | Mouse Col IV | Control 20 Treatment 50 | 7 d | 8 d | Rotarod test↑ MLPT scores↓ |
Qin et al. [46] | Intracerebral | 1 × 106 iPSCs | Rat Col VII | Sham 30 Control 63 Treatment 59 | 6 h | 14 d | MLPT scores↓ |
Qin et al. [44] | Intracerebral | 2 × 106 iPSCs | Rat Col VII | NA | 24 h | 14 d | mNSS↓ MLPT scores↓ |
Qin et al. [45] | Intracerebral | 1 × 106 iPSCs | Rat Col VII | Sham 12 Control 24 Treatment 12 | 24 h | 14 d | mNSS↓ MLPT scores↓ |
References | Drug delivery route | Number of cells/exosomes | Type of ICH model Rat | Sample size | Treatment day after ICH | Earliest effective time (post ICH) | Behavioral recovery |
---|---|---|---|---|---|---|---|
Seyfried et al. [86] | Intra-arterial | 1 × 106 MSCs | Rat ABI | Control 18 Treatment 18 | 24 h | 7 d | mNSS↓ corner-turn test↑ |
Li et al. [87] | Intra-arterial | 4 × 106 NSCs | Rat Col VII | Control 8 Treatment 40 | 2, 7, 14, 21 or 28 d | 28 d | Rotarod tests↑ beam-walking tests↑ limb-placing tests↑ spontaneous cycling tests↑ |
Zhang et al. [88] | Intra-arterial intravenous intraventricular | 2 × 106 MSCs | Rat Col VII | Blank 5 Sham 20 Control 20 Treatment 60 | 1, 3, 5 and 7 d | 24 h | Beam-walking test ↑ (intravenous group →) |
Xie et al. [89] | Intracerebral, intravenous | 2 × 105(IC) 2 × 106(IV) MSCs | Rat Col VII | Sham 10 Control 16 Treatment 36 | NA | 7 d | mNSS↓ |
Lee et al. [90] | Intravenous intracerebral | 5 × 106 (IV) 1 × 106 (IC) NSCs | Rat Col VII | Sham 30 Control 30 Treatment 120 | 2 h or 24 h | 24 h | MLPT scores↓ |
Reference | Drug delivery route | Number of cells/exosomes | Type of ICH Model Rat | Sample Size | Treatment day after ICH | Earliest effective time (post ICH) | Behavioral recovery |
---|---|---|---|---|---|---|---|
Sun et al. [60] | Intranasal | 1 × 106 MSCs | Mouse Col IV | NA | 3 d and 7 d | 14 d | mNSS↓ adhesive removal↑ rotarod tests↑ open field tests↑ |