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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Endoplasmic reticulum stress modulates the fate of lung resident mesenchymal stem cell to myofibroblast via C/EBP homologous protein during pulmonary fibrosis

Fig. 1

LR-MSC in IPF transformed to myofibroblast and suffered from ER stress. A HE and Masson’s staining of IPF lung show extensive fibroblastic foci and accumulation of extracellular matrix. B Quantification of CD90-positive cells in the normal or fibrotic area of IPF lung in each field. C Immunofluorescence of IPF and non-fibrotic (normal) lungs show the colocalization of LR-MSC marker CD90 and myofibroblast marker α-SMA. Arrows indicate positive staining of α-SMA in LR-MSC. The right panel shows the comparison between the percentage of α-SMA-positive CD90+ cells. D Immunofluorescence of IPF and non-fibrotic (normal) lungs shows CHOP expression in LR-MSC. The right panel shows the comparison between the percentage of CHOP-positive CD90+ cells

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Stem Cell Research & Therapy

ISSN: 1757-6512