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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Endoplasmic reticulum stress modulates the fate of lung resident mesenchymal stem cell to myofibroblast via C/EBP homologous protein during pulmonary fibrosis

Fig. 7

Schematic illustration of the mechanism by which ER stress is involved in pulmonary fibrosis by modulating myofibroblast differentiation of LR-MSC. On the one hand, ER stress during pulmonary fibrosis dampens the alveolar repair function of LR-MSC; on the other hand, it facilitates the activation of the TGFβ/SMAD signaling pathway and promotes the myofibroblast differentiation of LR-MSC to produce more ECM.

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Stem Cell Research & Therapy

ISSN: 1757-6512